Neural plasticity and adult neurogenesis: the deep biology perspective
Anna Maria Colangelo
Giovanni Cirillo
Lilia Alberghina
Michele Papa
Hans V.Westerhoff
摘要：The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration.Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies,amidst the danger of neuroinflammation.We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies.Distinct pathways need to be regulated,ranging from neural growth factor induced differentiation to mitochondrial bioenergetics,reactive oxygen metabolism,and apoptosis.Requiring much Gibbs energy consumption,brain depends on aerobic energy metabolism,hence on mitochondrial activity.Mitochondrial fission and fusion,movement and perhaps even mitoptosis,thereby come into play.All these network processes are interlinked and involve a plethora of molecules.We recommend a deep thinking approach to adult neurobiology.
机标关键词：
资助基金：Synpol(KBBE.2012.3.4-02 #311815)Corbel(NFRADEV-4-2014-2015#6542 48)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 201-205 )
英文信息