Emerging roles for insulin-like growth factor binding protein like protein 1
Yingqian Li
Eric Zhao
Dong Feng Chen
摘要：Insulin-like growth factors (IGFs) mediate diverse cellular processes in various tissues,including the central nervous system (CNS) and thus require robust and delicate regulatory mechanisms.It is now known that IGF signaling is regulated by a superfamily of IGF binding proteins (IGFBPs) which share significant sequence homology and are secreted to the extracellular environment to bind IGF (Nguyen et al.,2013).Currently,there are 6 known IGFBPs and 10 IGFBP related proteins.A new member of the IGFBP superfamily,IGFBP like protein 1 (IGFBPL1),was then identified and shown to have tumor suppressor like properties (Smith et al.,2007).Since then,little has been reported about the physiological roles of IGFBPL1.Recently,IGFBPL1 was found to be critically involved in mediating IGF-1 signaling to control CNS axon growth and regeneration (Guo et al.,2018).The study has uncovered a new signaling loop in the regulation of the pleiotropic functions of IGF1 and presents a possible novel pharmacological manipulation for promoting nerve regeneration and repair.
机标关键词：
资助基金：grants from the National Institutes of Health(EY025913 and EY025259)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 258-259 )