Stem cell-based in utero therapies for spina bifida: implications for neural regeneration
Connor Long
Lee Lankford
Aijun Wang
摘要：The history:Myelomeningocele-also known as spina bifida -is a devastating congenital anomaly of the central nervous system that is caused by the malformation of the spinal cord and vertebral column during embryogenesis.Depending on the location of the spina bifida lesion on the spine,patients suffer from neurological dysfunction ranging from paresis and incontinence to complete paralysis.The current standard of care for spina bifida is in utero surgical repair of the defect,which has been shown to minimize the secondary deficits associated with this disorder (Adzick et al.,2011).Despite these successes,this approach does not reliably improve neurologic function of affected children.Several groups,including our own,have performed studies aimed at augmenting the in utero surgical repair of spina bifida by applying principles of stem cell and tissue engineering to provide an enhanced protection of the exposed neural elements (Saadai et al.,2011,2013;Wang et al.,2015;Brown et al.,2016).The ultimate goal of these studies is to improve the neurologic function in patients while maintaining the benefits of the existing fetal surgical treatment.
机标关键词：
资助基金：This work was in part supported by NIH(5R01NS100761-02.5R03HD091601-02)Shriners Hospital for Children research grants(87410-NCA-17 and 85119-NCA-18)March of Dimes Foundation (No.5FY1682)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 260-261 )