Lessons from tenascin-C knockout mice and potential clinical application to subarachnoid hemorrhage
Masato Shiba
Hidenori Suzuki
摘要：Subarachnoid hemorrhage by a ruptured cerebral aneurysm remains the most devastating cerebrovascular disorders with high morbidity and mortality (Suzuki et al.,2017),which are mainly caused by early brain injury and delayed cerebral ischemia.Despite many experimental and clinical research efforts,the mechanisms of early brain injury as well as delayed cerebral ischemia remain unclarified.However,recent works have suggested that tenascin-C,which is a special type of secreted extracellular matrix proteins,is promising as a novel therapeutic target against post-subarachnoid hemorrhage early brain injury and delayed cerebral ischemia.
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资助基金：This work was funded by a grant-in-aid for Scientific Research from Japan Society for the Promotion of Science,(No.17K10825)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 262-264 )