Diffusion kurtosis imaging of microstructural changes in brain tissue affected by acute ischemic stroke in different locations
Liu-Hong Zhu
Zhong-Ping Zhang
Fu-Nan Wang
Qi-Hua Cheng
Gang Guo
摘要：The location of an acute ischemic stroke is associated with its prognosis.The widely used Gaussian model-based parameter,apparent diffusion coefficient (ADC),cannot reveal microstructural changes in different locations or the degree of infarction.This prospective observational study was reviewed and approved by the Institutional Review Board of Xiamen Second Hospital,China (approval No.2014002).Diffusion kurtosis imaging (DKI) was used to detect 199 lesions in 156 patients with acute ischemic stroke (61 males and 95 females),mean age 63.15 + 12.34 years.A total of 199 lesions were located in the periventricular white matter (n =52),corpus callosum (n =14),cerebellum (n =29),basal ganglia and thalamus (n =21),brainstem (n =21) and gray-white matter junctions (n =62).Percentage changes of apparent diffusion coefficient (ΔADC) and DKI-derived indices (fractional anisotropy [ΔFA],mean diffusivity [ΔMD],axial diffusivity [ΔDa],radial diffusivity ΔDr,mean kurtosis [ΔMK],axial kurtosis [ΔKa],and radial kurtosis [ΔKr]) of each lesion were computed relative to the normal contralateral region.The results showed that (1) there was no significant difference in ΔADC,ΔMD,ΔDa or ΔDr among almost all locations.(2) There was significant difference in ΔMK among almost all locations (except basal ganglia and thalamus vs.brain stem;basal ganglia and thalamus vs.gray-white matter junctions;and brainstem vs.gray-white matter junctions.(3) The degree of change in diffusional kurtosis in descending order was as follows:corpus callosum ＞ periventricular white matter ＞ brainstem ＞ gray-white matter junctions ＞ basal ganglia and thalamus ＞ cerebellum.In conclusion,DKI could reveal the differences in microstructure changes among various locations affected by acute ischemic stroke,and performed better than diffusivity among all groups.
机标关键词：
分类号：R445(诊断学)R741(神经病学)
资助基金：This study was supported by the Science and Technology Planned Project from Xiamen Science and Technology Bureau,China,(No.3502Z20154065)the Joint Project for Xiamen Key Diseases from Xiamen Science and Technology Bureau,China,(No.3502Z20149032)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 272-279 )
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