Rehabilitation following spinal cord injury: how animal models can help our understanding of exercise-induced neuroplasticity
Kristina Loy
Florence M. Bareyre
摘要：Spinal cord injury is a devastating condition that is followed by long and often unsuccessful recovery after trauma. The state of the art approach to manage paralysis and concomitant impairments is rehabilitation, which is the only strategy that has proven to be effective and beneficial for the patients over the last de-cades. How rehabilitation influences the remodeling of spinal axonal connections in patients is important to understand, in order to better target these changes and define the optimal timing and onset of training. While clinically the answers to these questions remain difcult to obtain, rodent models of rehabilitation like bicycling, treadmill training, swimming, enriched environments or wheel running that mimic clinical rehabilitation can be helpful to reveal the axonal changes underlying motor recovery. This review will focus on the different animal models of spinal cord injury rehabilitation and the underlying changes in neuronal networks that are improved by exercise and rehabilitation.
机标关键词：
资助基金：Work in FMB laboratory is supported by grants from the Deutsche Forschungsgemeinschaft(DFG)Work in FMB laboratory is supported by grants from the Deutsche Forschungsgemeinschaft( SFB870)the Wings for Life foundation. FMB is also supported by the Munich Center for Systems Neurology(DFG)the Wings for Life foundation. FMB is also supported by the Munich Center for Systems Neurology( SyNergy)the Wings for Life foundation. FMB is also supported by the Munich Center for Systems Neurology(EXC 1010)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 405-412 )
英文信息