Motor inhibition effciency in healthy aging: the role of γ-aminobutyric acid
Lisa Pauwels
Celine Maes
Lize Hermans
Stephan P. Swinnen
摘要：The ability to cancel a motor response is critical for optimal functioning in various facets of daily life. Hence, efficient inhibitory motor control is a key function throughout the lifespan. Considering the fact that inhibitory motor function gradually declines with advancing age, it is not surprising that the study of motor inhibition in this age group is gaining considerable interest. In general, we can distinguish between two prominent types of motor inhibition, namely proactive and reactive inhibition. Whereas the anticipa-tion for upcoming stops (proactive inhibition) appears readily preserved at older age, the ability to stop an already planned or initiated action (reactive inhibition) generally declines with advancing age. The differen-tial impact of aging on proactive and reactive inhibition at the behavioral level prompts questions about the neural architecture underlying both types of inhibitory motor control. Here we will not only highlight the underlying structural brain properties of proactive and reactive inhibitory control but we will also discuss recent developments in brain-behavioral approaches, namely the registration of neurochemical compounds using magnetic resonance spectroscopy. This technique allows for the direct detection of the primary in-hibitory neurotransmitter in the brain,i.e., γ-aminobutyric acid, across the broader cortical/subcortical territory, thereby opening new perspectives for better understanding the neural mechanisms mediating efficient inhibitory control in the context of healthy aging. Ultimately, these insights may contribute to the development of interventions specifically designed to counteract age-related declines in motor inhibition.
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资助基金：The work was supported by the Research Foun-dation Flanders(G089818N)The work was supported by the Research Foun-dation Flanders( to SPS)the Excellence of Science grant(EOS)the Excellence of Science grant( 30446199)the Excellence of Science grant( MEMODYN)the Excellence of Science grant( to SPS)the KU Leuven Research Fund(C16/15/070)the KU Leuven Research Fund( to SPS)the postdoctoral fellowship from the Research Fund KU Leuven(PDM/18/180)the postdoctoral fellowship from the Research Fund KU Leuven( to LP)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 741-744 )
英文信息