Assessing gray matter volume in patients with idiopathic rapid eye movement sleep behavior disorder
Xian-Hua Han
Xiu-Ming Li
Wei-Jun Tang
Huan Yu
Ping Wu
Jing-Jie Ge
Jian Wang
Chuan-Tao Zuo
Kuang-Yu Shi
摘要：Idiopathic rapid eye movement sleep behavior disorder (iRBD) is often a precursor to neurodegenerative disease. However, voxel-based mor-phological studies evaluating structural abnormalities in the brains of iRBD patients are relatively rare. This study aimed to explore cerebral structural alterations using magnetic resonance imaging and to determine their association with clinical parameters in iRBD patients. Brain structural T1-weighted MRI scans were acquired from 19 polysomnogram-confirmed iRBD patients (male:female 16:3; mean age 66.6± 7.0 years) and 20 age-matched healthy controls (male:female 5:15; mean age 63.7± 5.9 years). Gray matter volume (GMV) data were analyzed based on Statistical Parametric Mapping 8, using a voxel-based morphometry method and two-samplet-test and multiple regression anal-ysis. Compared with controls, iRBD patients had increased GMV in the middle temporal gyrus and cerebellar posterior lobe, but decreased GMV in the Rolandic operculum, postcentral gyrus, insular lobe, cingulate gyrus, precuneus, rectus gyrus, and superior frontal gyrus. iRBD duration was positively correlated with GMV in the precuneus, cuneus, superior parietal gyrus, postcentral gyrus, posterior cingulate gyrus, hippocampus, lingual gyrus, middle occipital gyrus, middle temporal gyrus, and cerebellum posterior lobe. Furthermore, phasic chin electro-myographic activity was positively correlated with GMV in the hippocampus, precuneus, fusiform gyrus, precentral gyrus, superior frontal gyrus, cuneus, inferior parietal lobule, angular gyrus, superior parietal gyrus, paracentral lobule, and cerebellar posterior lobe. There were no significant negative correlations of brain GMV with disease duration or electromyographic activity in iRBD patients. ThThese findings expand the spectrum of known gray matter modifications in iRBD patients and provide evidence of a correlation between brain dysfunction and clinical manifestations in such patients. The protocol was approved by the Ethics Committee of Huashan Hospital (approval No. KY2013-336) on January 6, 2014. This trial was registered in the ISRCTN registry (ISRCTN18238599).
机标关键词：
分类号：R445(诊断学)R741(神经病学)
资助基金：This study was supported by the China-US Biomedical Collaborative Research Program, (No. 81361120393)the National Natural Science Foundation of China, (No. 81401135)Shanghai Sailing Program, (No. 18YF1403100 (to JJG). The funding bodies played no role in the study design, in the collection, analysis and in-terpretation of data, in the writing of the paper, and in the decision to submit the paper for publication)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 868-875 )
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