Gene expression changes in dorsal root ganglia following peripheral nerve injury: roles in inflammation, cell death and nociception
Sarah L.Martin
Adam J.Reid
Alexei Verkhratsky
Valerio Magnaghi
Alessandro Faroni
摘要：Subsequent to a peripheral nerve injury, there are changes in gene expression within the dorsal root ganglia in response to the damage. This review selects factors which are well-known to be vital for inflammation, cell death and nociception, and highlights how alterations in their gene expression within the dorsal root ganglia can affect functional recovery. The majority of studies used polymerase chain reaction within animal models to analyse the dynamic changes following peripheral nerve injuries. This review aims to highlight the factors at the gene expression level that impede functional recovery and are hence are potential targets for therapeutic approaches. Where possible the experimental model, specific time-points and cellular location of expression levels are reported.
机标关键词：
资助基金：The work was supported by the Hargreaves and Ball Trust, the National Institute for Health Research (II-LA-0313-20003)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 939-947 )
英文信息