Preliminary in vitro evaluation of neuroprotective and monoamine oxidase type B inhibitory effects of newly synthesized 8-aminocaffeines
Magdalena Kondeva-Burdina
Maya Georgieva
Alexandra Kasabova-Angelova
Virginia Tzankova
Alexander Zlatkov
摘要：The expected growth of the elderly population at highest risk for Parkinson's disease (PD) in the next decades makes the identifcation of factors that promote or prevent the disease an important goal. In addition, new therapies -aiming to delay the progression of PD are also needed (Prediger, 2010). However, there have been few clinical trials designed to investigate neuroprotection. Tus the application of an appropriate in vitro model such as the neuroblastoma SH-SY5Y cell line is extremely helpful. Tese cells were selected due to its human origin, catecholaminergic neuronal properties, and ease of maintenance (Xicoy et al., 2017).
机标关键词：
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 971-972 )