The role of degenerative pathways in the development of irreversible consequences after brain ischemia
Ryszard Pluta
Marzena U(l)amek-Kozio(l)
摘要：Ischemic stroke and irreversible consequences: Ischemic stroke in humans is the second most common cause of death in the world (Mozaffarian et al., 2016). The outcomes after a stroke are often dependent on complications, including motor disorders, depression and dementia (Pluta et al., 2018a), which causes a high risk of re-hospitalization and/or palliative care. Tis is also the main reason for long-term disability in people afer stroke, with up to half of those who survived the stroke will not regain their independence until the end of their lives (Moza?arian et al., 2016). According to epidemiological forecasts, human ischemic stroke will soon become the dominant cause of death worldwide (Bejot et al., 2016) as well as dementia with the phenotype of Alzheimer's disease (AD;Kim and Lee 2018). It is suggested that human ischemic stroke and experimental brain ischemia in animals are associated with the possible development of AD neuropathology (Pluta et al., 2018a). Epidemiological observations have shown that brain ischemia is a contributing factor to the development of AD and vice versa. Below we present the latest advances in the investigation of brain ischemia-reperfusion injury, focusing on ischemia-induced of the AD phenotype and genotype in humans and animals. We focus in this report on the very likely association between β-amyloid peptide and tau protein in humans (Qi et al., 2007) and animals with post-ischemic irreversible neurodegenerative processes and development dementia. It should be emphasized that despite the fact that stroke in humans is one of the main causes of disability, dementia and death in the world, it has no e?ective therapy improving outcome of the functional and structural irreversible consequences of this disease.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 982-983 )