Decreased numbers of circulating endothelial progenitor cells are associated with hyperglycemia in patients with traumatic brain injury
Hui-Jie Wei
Li Liu
Fang-Lian Chen
Dong Wang
Liang Wang
Zeng-Guang Wang
Rong-Cai Jiang
Jing-Fei Dong
Jie-Li Chen
Jian-Ning Zhang
摘要：Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their function.However, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients with traumatic brain injury is unclear. In this study, 101 traumatic brain injury patients admitted to the Department of Neurosurgery, Tianjin Medical University General Hospital or the Department of Neurosurgery, Tianjin Huanhu Hospital, China, were enrolled from April 2005 to March 2007. The number of circulating endothelial progenitor cells and blood glucose levels were measured at 1, 4, 7, 14 and 21 days after traumatic brain injury by flow cytometry and automatic biochemical analysis, respectively. The number of circulating endothelial progenitor cells and blood sugar levels in 37 healthy control subjects were also examined. Compared with controls, the number of circulating endothelial progenitor cells in traumatic brain injury patients was decreased at 1 day after injury, and then increased at 4 days after injury, and reached a peak at 7 days after injury. Compared with controls, blood glucose levels in traumatic brain injury patients peaked at 1 day and then decreased until 7 days and then remained stable. At 1, 4, and 7 days after injury, the number of circulating endothelial progenitor cells was negatively correlated with blood sugar levels (r =-0.147, P < 0.05). Our results verify that hyperglycemia in patients with traumatic brain injury is associated with decreased numbers of circulating endothelial progenitor cells. This study was approved by the Ethical Committee of Tianjin Medical University General Hospital, China (approval No. 200501) in January 2015.
机标关键词：
资助基金：the National Natural Science Foundation of China, (No. 30772229)the Natural Science Foundation of Tianjin of China, (No. 12JCQNJC06800)the Science and Technology Projects in Key Areas of Traditional Chinese Medicine of Tianjin of China, (No. 2018001)the Scientifc Research Program Project of Tianjin Education Commission of China, (No. 2018ZD03)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 984-990 )
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