Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of Yin Yang 1 in the brain?
Zhefan Stephen Chen
Ho Yin Edwin Chan
摘要：Yin Yang 1 (YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types, including neurons.It controls neuronal differentiation, as well as neuronal specification and migration during the development of the mammalian nervous system.Besides, YY1 also mediates the transcription of genes that are required for neuronal survival.An impairment of the transcriptional function of YY1 causes neuronal death.This review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative disorders.The expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms, including recruitment to protein aggregates, protein degradation and aberrant nuclear/cytoplasmic shuttling.Understanding the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.
机标关键词：
资助基金：the General Research Fund (14100714)The Chinese University of Hong Kong Vice-Chancellor's One-Off Discretionary Fund (VCF2014011)The Chinese University of Hong Kong One-of Funding for Joint Lab/Research Collaboration (3132980)The Chinese University of Hong Kong Faculty of Science Strategic Development Fund (FACULTY-P17173)The Chinese University of Hong Kong Gerald Choa Neuroscience Centre (7105306)donations from Chow Tai Fook Charity Foundation (6903898)Hong Kong Spinocerebellar Ataxia Association (6903291)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1148-1151 )
英文信息