Aberrant cell cycle induction is pivotal for mitochondrial biogenesis after traumatic brain injury
Nilkantha Sen
摘要：Cell cycle regulation and brain injury: Traumatic brain injury (TBI) is one of the primary causes of morbidity and mortality in patients, and it affects more than 1.7 million Americans each year. Other than direct damage resulting from TBI, the brain injury triggers several secondary mechanisms which either individually or in combination contribute to the neurological deficits after TBI (Gupta and Sen, 2016). These secondary mechanisms include neuronal death and stimulate proliferation of astrocytes and microglial cells, which in turn triggers neuro-inflammation (Simon et al., 2017). The association between proliferation of dividing cells like astrocytes and microglia with cell cycle has already been highlighted in a recent publication (Simon et al., 2017). However, in this article, we will emphasize the importance of cell cycle in post-mitotic cells like mature neurons following brain injury.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1215-1216 )