Therapeutic strategies for peripheral nerve injury: decellularized nerve conduits and Schwann cell transplantation
Gong-Hai Han
Jiang Peng
Ping Liu
Xiao Ding
Shuai Wei
Sheng Lu
Yu Wang
摘要：In recent years,the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention.Animal-based studies show that the transplantation of Schwann cells in combination with nerve scaffolds promotes the repair of injured peripheral nerves.Autologous Schwann cell transplantation in humans has been reported recently.This article reviews current methods for removing the extracellular matrix and analyzes its composition and function.The development and secretory products of Schwann cells are also reviewed.The methods for the repair of peripheral nerve injuries that use myelin and Schwann cell transplantation are assessed.This survey of the literature data shows that using a decellularized nerve conduit combined with Schwann cells represents an effective strategy for the treatment of peripheral nerve injury.This analysis provides a comprehensive basis on which to make clinical decisions for the repair of peripheral nerve injury.
机标关键词：
资助基金：the National Key R & D Program of China,(No.2017YFA0104701)the National Natural Science Foundation of China,(No.31771052)the Natural Science Foundation of Beijing of China,(No.7172202)the PLA Youth Training Project for Medical Science of China,(No.16QNP144)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1343-1351 )
英文信息