Role and prospects of regenerative biomaterials in the repair of spinal cord injury
Shuo Liu
Yuan-Yuan Xie
Bin Wang
摘要：Axonal junction defects and an inhibitory environment after spinal cord injury seriously hinder the regeneration of damaged tissues and neuronal functions.At the site of spinal cord injury,regenerative biomaterials can fill cavities,deliver curative drugs,and provide adsorption sites for transplanted or host cells.Some regenerative biomaterials can also inhibit apoptosis,inflammation and glial scar formation,or further promote neurogenesis,axonal growth and angiogenesis.This review summarized a variety of biomaterial scaffolds made of natural,synthetic,and combined materials applied to spinal cord injury repair.Although these biomaterial scaffolds have shown a certain therapeutic effect in spinal cord injury repair,there are still many problems to be resolved,such as product standards and material safety and effectiveness.
机标关键词：
资助基金：the National Natural Science Foundation of China,(No.81571213)the Medical Science and Technique Development Foundation of Nanjing of China,(No.QRX17006)the Medical Science and Innovation Platform of Nanjing of China,(No.ZDX16005)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 1352-1363 )
英文信息