Rac GTPases: domain-specific functions in neuronal development
Steffen Nφrgaard
Roger Pocock
摘要：Understanding fundamental mechanisms governing axon outgrowth and guidance can inform the development of therapeutic strategies to restore neuronal function damaged though injury or disease.Axons navigate the extracellular environment by responding to guidance cues that bind to cell surface recep tors to relay information intracellularly via Rho GTPase family members,including the Rac GTPases.Rac GTPases act as master switches to regulate diverse signalling pathways to control the actin cytoskeleton-a major driver of axon outgrowth.However,scant evidence exists concerning how different domains within Rac GTPases regulate specific neurodevelopmental events,such as axon outgrowth and guidance.
机标关键词：
资助基金：a grant from an NHMRC Project Grant(GNT1105374)NHMRC Senior Research Fellowship(GNT1137645)a Victorian Endowment for Science,Knowledge and Innovation Fellowship (VIF23)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1367-1368 )