Galectin-3 prospects as a therapeutic agent for multiple sclerosis
Laura Thomas
Laura Andrea Pasquini
摘要：Galectin-3 (Gal-3) in oligodendrocyte (OLG) differentiation:OLGs are the cells in charge of myelination in the central nervous system (CNS),allowing rapid conduction of the neural action potential and giving trophic support to axons.OLGs undergo a series of changes throughout their life cycle:first,upon neural stem cell commitment to the OLG lineage,cells referred to as OLG precursor cells (OPC) present a bipolar morphology,have proliferative and migratory capacity and express molecular markers like platelet-derived growth factor receptor alpha and neural/glial antigen 2;next,in an intermediate stage called preOLG,OLGs are more ramified and express CNPase,Olig1 and O4,among others;finally,cells develop into myelin forming cells which express molecular markers like myelin basic protein (MBP),adenomatous polyposis polyposis and proteolipid protein (Franklin et al.,2017).
机标关键词：
资助基金：grants from Agencia Nacional de Promoción Científica y Tecnológica(Argentina)grants from Agencia Nacional de Promoción Científica y Tecnológica(PICT 2014-3116)Universidad de Buenos Aires(20920160100683BA)Universidad de Buenos Aires(to LAP)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1380-1382 )