Compartmentalized necroptosis activation in excitotoxicity-induced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology
Macarena S.Arrázola
Felipe A.Court
摘要：Excitotoxicity and neuronal cell death:Glutamate is the main excitatory neurotransmitter of the central nervous system and functionally involved in most brain activities,includingbrain development,synaptic plasticity,learning and memory.Excitatory synaptic transmission is primarily mediated by ligand-gated ion channels,including ct-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA),N-methyl-D-aspartate (NMDA) and kainate receptors.
机标关键词：
资助基金：This work was funded by grants from Geroscience Center for Brain Health and Metabolism(FONDAP-15150012)This work was funded by grants from Geroscience Center for Brain Health and Metabolism(to FC)Fondo Nacional de Desarrollo Científico y Tecnológico(FONDECYT)Fondo Nacional de Desarrollo Científico y Tecnológico(1150766)Fondo Nacional de Desarrollo Científico y Tecnológico(to FC)Comisión Nacional de Investigación Científica y Tecnológica,Fondecyt de Postdoctorado Project(3180313)Comisión Nacional de Investigación Científica y Tecnológica,Fondecyt de Postdoctorado Project(to MA)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1385-1386 )