Spinal cord organoids add an extra dimension to traditional motor neuron cultures
Winanto
Zi-Jian Khong
Jin-Hui Hor
Shi-Yan Ng
摘要：Since Lancaster et al. (2013) first described the formation of self-or-ganizing cerebral organoids for modeling neurodevelopmental disorders, it became evident that three-dimensional (3D) neural organoid cultures are more superior systems for modeling neurode-velopment and neurodegeneration in human. The use of a spinning bioreactor to grow organoids allows better nutrient absorption and enhances formation of neuroepithelial-like zones, making it a great tool to study neurodevelopment and neurodegeneration. Neural organoids are 3D cell culture systems formed by proliferating, dif-ferentiating, migrating and self-organizing pools of neural progen-itors. They mimic brain structures in their cell type composition, cytoarchitecture, and to some extent maturity and functionality (Lancaster et al., 2013).
机标关键词：
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1515-1516 )