Sodium butyrate prevents radiation-induced cognitive impairment by restoring pCREB/BDNF expression
Hae June Lee
Yeonghoon Son
Minyoung Lee
Changjong Moon
Sung Ho Kim
In Sik Shin
Miyoung Yang
Sangwoo Bae
Joong Sun Kim
摘要：Sodium butyrate is a histone deacetylase inhibitor that affects various types of brain damages. To investi-gate the effects of sodium butyrate on hippocampal dysfunction that occurs after whole-brain irradiation in animal models and the effect of sodium butyrate on radiation exposure-induced cognitive impairments, adult C57BL/6 mice were intraperitoneally treated with 0.6 g/kg sodium butyrate before exposure to 10 Gy cranial irradiation. Cognitive impairment in adult C57BL/6 mice was evaluated via an object recognition test 30 days after irradiation. We also detected the expression levels of neurogenic cell markers (doublecortin) and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor. Radia-tion-exposed mice had decreased cognitive function and hippocampal doublecortin and phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. Sodium butyrate pretreatment reversed these changes. These findings suggest that sodium butyrate can improve radia-tion-induced cognitive dysfunction through inhibiting the decrease in hippocampal phosphorylated cAMP response element binding protein/brain-derived neurotrophic factor expression. The study procedures were approved by the Institutional Animal Care and Use Committee of Korea Institute of Radiological Medical Sciences (approval No. KIRAMS16-0002) on December 30, 2016.
机标关键词：
分类号：R453(治疗学)R363(病理学)R741(神经病学)
资助基金：the Nuclear Research and Development Program (NRF-2012M2A2A7012377)the Nuclear Research and Development Program ( NRF-2015M2B2B1068627 and NRF-2015R1C1A2A01053041) of the National Research Foundation of Korea (NRF)ICT & Future Planning. Financial support(NRF-2012M2A2A7012377)ICT & Future Planning. Financial support( NRF-2015M2B2B1068627 and NRF-2015R1C1A2A01053041) of the National Research Foundation of Korea (NRF)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1530-1535 )
英文信息