Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study
Sung Ho Jang
Seong Ho Kim
Han Do Lee
摘要：The cingulum, connecting the orbitofrontal cortex to the medial temporal lobe, involves in diverse cogni-tion functions including attention, memory, and motivation. To investigate the relationship between the cingulum injury and cognitive impairment in patients with chronic mild traumatic brain injury, we evaluat-ed the integrity between the anterior cingulum and the basal forebrain using diffusion tensor tractography in 73 patients with chronic mild traumatic brain injury (39 males, 34 females, age 43.29 ± 11.42 years) and 40 healthy controls (22 males, 18 females, age 40.11 ± 16.81 years). The patients were divided into three subgroups based on the integrity between the anterior cingulum and the basal forebrain on diffusion tensor tractography: subgroup A (n = 19 patients) - both sides of the anterior cingulum were intact; subgroup B (n= 36 patients) - either side of the anterior cingulum was intact; and subgroup C (18 patients) - both sides of the anterior cingulum were discontinued. There were significant differences in total Memory Assessment Scale score between subgroups A and B and between subgroups A and C. There were no significant differ-ences in diffusion tensor tractography parameters (fractional anisotropy, apparent diffusion coeffcient, and fiber volume) between patients and controls. These findings suggest that the integrity between the anterior cingulum and the basal forebrain, but not diffusion tensor tractography parameter, can be used to predict the cognitive function of patients with chronic mild traumatic brain injury. This study was approved by Yeungnam University Hospital Institutional Review Board (approval No. YUMC-2014-01-425-010) on August 16, 2017.
机标关键词：
分类号：R445(诊断学)R741(神经病学)
资助基金：the Medical Research Center Program (2015R1A5A2009124) through the National Research Foundation of Korea (NRF)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 1556-1561 )
英文信息