Gamma-aminobutyric acid (GABA) promotes recovery from spinal cord injury in lampreys: role of GABA receptors and perspective on the translation to mammals
Daniel Romaus-Sanjurjo
María Celina Rodicio
Antón Barreiro-Iglesias
摘要：In mammals, spinal cord injury (SCI) is a devastating event that can lead to a permanent loss of motor, sensory and autonomic functions below the site of injury. In the last years, the role of different neurotransmitter systems on re-generation and recovery from SCI has been deciphered. For example, studies in lampreys have shown that neurotransmitters play a key role in modulating the survival and regeneration of brainstem descending neurons after SCI (Ro-maus-Sanjurjo et al., 2018; Sobrido-Cameán et al., 2018). Glutamate is known to play a prominent role after SCI since it causes excitotoxicity to non-injured neurons during the secondary phase after a traumatic injury both in mam-mals and lampreys (Fernández-López et al., 2014). In contrast, recent work in lampreys has shown that γ-aminobutyric acid (GABA) can play a neuro-protective and pro-regenerative role after SCI (Romaus-Sanjurjo et al., 2018). GABA is the main inhibitory neurotransmitter in the central nervous system (CNS) of vertebrates, and acts through both metabotropic G-protein-coupled GABAB receptors, and ionotropic ligand-gated chloride channel GABAA re-ceptors. Here, we discuss recent work from our group and others on the pos-sible role of different GABA receptors in neuronal survival and regeneration after SCI and provide a perspective on future work in this field.
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资助基金：grants from Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund 2007–2013(BFU2014-56300-P and BFU-2017-87079-P)a fellowship from EMBO(7010)a fellowship from EMBO( to DRS)a grant from the Xunta de Galicia(2016-PG008)a grant from the Xunta de Galicia( to ABI)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1695-1696 )