Are the mechanisms involved in astrocyte and lymphocyte death during HIV infection similar?
Diego S. Ojeda
Andreas Till
Jorge Quarleri
摘要：Acquired immune deficiency syndrome is associated with the death of CD4+ T lymphocytes. The entry of the human immunodeficiency virus (HIV) into the central nervous system leads to a broad spectrum of HIV-associated neurocognitive disorders (HAND) ranging from mild to severe dementia. Inside the central nervous system, HIV establishes infection in astrocytes – the predominant cell type in the brain, thus causing neuropathology, but the underlying mechanisms remain un-known. Much research has been focused on the role of innate immune activation, prompted by abundance of soluble viral factors, abortive infection, or cytokines secreted by neighboring microglia and associ-ated with neuroinflammation and HAND. However, the mechanisms that prime and activate the inflammatory process during HIV infection have not been unraveled (Rawat et al., 2019).
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资助基金：the Argentinean National Agency of Scien-tific and Technological Promotion(PICT 2015-1921)by the University of Buenos Aires(20020110100034)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1707-1708 )