A different view on the pathophysiology of Parkinson’s disease: a descendent neurochemical hypothesis?
Burak yulug
Mehmet Ozansoy
Seyda Cankaya
摘要：It has been already shown that Parkinson’s disease (PD) is char-acterized by a prominent degeneration in substantia nigra (SN) neurons. Growing evidence suggests that there is a latent period of PD associated with slight non-motor findings such as olfac-tory dysfunction (Dickson et al., 2018). However, the potential biomarker role of olfactory dysfunction in PD has been a topic of great interest in the last years (Raskin et al., 1990; Dickson et al., 2018). The classical hypothesis of Braak suggests that PD begins as a synucleinopathy in the lower brainstem or in the ol-factory bulb (OB) that progresses rostrally to the SN and amyg-dala to cause parkinsonism at a later stage of the disease (Burke et al., 2008). However, Braak’s hypothesis should be cautiously interpreted since this scheme is not based on the distribution of neuronal cell loss, but on the distribution of the accumulation of abnormal α-synuclein aggregates which leaves unanswered how it relates to the progression of neurochemical changes.
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1717-1718 )