Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?
Fernando Lucas-Ruiz
Caridad Galindo-Romero
David García-Bernal
María Norte-Mu?oz
Kristy T. Rodríguez-Ramírez
Manuel Salinas-Navarro
Jose E. Millán-Rivero
Manuel Vidal-Sanz
Marta Agudo-Barriuso
摘要：Mesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adi-pose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e., Wharton’s jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.
机标关键词：
资助基金：Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia (19881/GERM/15 to MVS)Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia(19881/GERM/15 to MVS)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 1851-1857 )
英文信息