Therapeutic implications of advanced age at time of spinal cord injury
Andrew N. Stewart
John C. Gensel
Bei Zhang
摘要：A recent demographic shift towards increased age at time of spi-nal cord injury (SCI), as well as decreased functional recovery following SCI in older populations, create the need to investigate how age effects SCI pathology and repair (Scivoletto et al., 2003). While decreased neuroplasticity or physical strength with age may contribute to functional deficits, work from our lab and others have identified exacerbated acute inflammatory events as contributors to age-dependent secondary injury. Specifically, our recent paper identified that increased production of reactive oxygen species (ROS) from macrophage nicotinamide adenine dinucleotide phos-phate (NADPH) oxidase (NOX) with age exacerbates secondary injury after SCI (Zhang et al., 2019). Collectively, we identified ROS as instrumental in worsening functional outcomes following aged SCI and demonstrated that the therapeutic efcacy of ROS based treatments is age-dependent. This short review focuses on the role of age on worsening functional outcomes following SCI and pro-vides a mechanistic overview into how age exaggerates secondary injury.
机标关键词：
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1895-1896 )