Physiological and pathological effects of amyloid-β species in neural stem cell biology
Adela Bernabeu-Zornoza
Raquel Coronel
Charlotte Palmer
María Monteagudo
Alberto Zambrano
Isabel Liste
摘要：Although amyloid-β peptide is considered neurotoxic, it may mediate several physiological processes during embryonic development and in the adult brain. The pathological function of amyloid-β peptide has been ex-tensively studied due to its implication in Alzheimer’s disease, but its physiological function remains poorly understood. Amyloid-β peptide can be detected in non-aggregated (monomeric) and aggregated (oligomeric and fibrillary) forms. Each form has different cytotoxic and/or physiological properties, so amyloid-β pep-tide and its role in Alzheimer’s disease need to be studied further. Neural stem cells and neural precursor cells are good tools for the study on neurodegenerative diseases and can provide future therapeutic applica-tions in diseases such as Alzheimer’s disease. In this review, we provide an outline of the effects of amyloid-β peptide, in monomeric and aggregated forms, on the biology of neural stem cells/neural precursor cells, and discuss the controversies. We also describe the possible molecular targets that could be implicated in these effects, especially GSK3β. A better understanding of amyloid-β peptide (both physiological and pathologi-cal), and the signaling pathways involved are essential to advance the field of Alzheimer’s disease.
机标关键词：
资助基金：grants from the MICINN-ISCIII(PI-10/00291 and MPY1412/09)MINECO(SAF2015-71140-R)Comunidad de Madrid (NEUROSTEMCM consortium)Comunidad de Madrid ( S2010/BMD-2336)Comunidad de Madrid (NEUROSTEMCM consortium)Comunidad de Madrid (S2010/BMD-2336)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 2035-2042 )
英文信息