Engineering nerve guidance conduits with three-dimenisonal bioprinting technology for long gap peripheral nerve regeneration
Jian Du
Xiaofeng Jia
摘要：Nerve guidance conduits (NGCs) are tubular structures that are used to bridge the gap of a severed nerve, thereby acting as a guide and protective micro-environment for the regenerating axons and as a barrier against the in-growth of scar-forming tissue. In the last few decades, the concept of NGCs has evolved from a research tool to investigate nerve regeneration into a translational product that is now being used clinically as an alternative for autologous nerve graft repair, due to their availability and ease of fabrication. At the moment, various nerve conduits have been approved for clinical use and are being marketed, including NeurotubeTM (K983007, 1999), SalubridgeTM (K002098, 2000), NeuraGenTM (K011168, 2001), SurgisisTM Nerve Cuff (K031069, 2003), NeurolacTM (K050573, 2005; K112267, 2011), CovaTM ORTHO-NERVE (K103081, 2012), ReaxonTM Plus (K143711, 2015) (Du et al., 2018a). However, clin-ical outcomes associated with the use of artificial nerve conduits are often inferior to that of autografts, particularly over long lesion gaps. Although their clinical use has been limited, mainly to the re-pair of relatively small defects (< 3 cm), such as small-caliber digital nerves, the potential for extending their clinical application to the repair of larger defects and larger mixed or motor nerves has made the development of an ideal nerve tube appealing for both scientists and the medical device industry.
机标关键词：
资助基金：This work was partially supported by Maryland Stem Cell Research Fund(2018-MSCRFD-4271)This work was partially supported by Maryland Stem Cell Research Fund( to XJ)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2073-2074 )