Three-dimensional motion analysis for evaluating motor function in rodents with peripheral nerve injury
Akira Ito
Wang Tianshu
Junichi Tajino
摘要：Peripheral nerves act like networks of "wires" that conduct signals from the brain and spinal cord to organs throughout the body. Damage to these nerves leads to numbness, pain, and weakness that eventually reduces the patient’s quality of life. Fortunately, peripheral nerves have a high regenerative capacity and, in most cases, recover from mild disorders and injuries. However, there have been contin-uous challenges facing the development of treatments for peripheral nerve conditions such as disorders that occur through chronic me-chanical stimulation like carpal tunnel syndrome, disorders due to side effects from drugs and intractable diseases like chronic inflam-matory demyelinating polyneuropathy. Furthermore, self-regener-ation becomes difcult when trauma causes a large gap in the axon, leading to the patient needing nerve transplantation. While autolo-gous nerve transplantation is the current gold standard, only approx-imately half of the cases obtain satisfactory functional recovery (Yang et al., 2011). More endeavors are needed to achieve better therapeutic effect with this treatment method.
机标关键词：
资助基金：Japan Society for the Promotion of Science (JSPS) KAKENHI (JP17K13052)Japan Society for the Promotion of Science ( JP18H03129)Japan Society for the Promotion of Science ( and JP18K19739)
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2077-2078 )