Glyphosate-based herbicide: a risk factor for demyelinating conditions of the peripheral nervous system?
Fabian Szepanowski
Christoph Kleinschnitz
Mark Stettner
摘要：Glyphosate is a broad-spectrum herbicide originally introduced to the market in 1974 by the agrochemical company Monsanto. More than 40 years down the line, glyphosate has become one of the most economically meaningful herbicides, with a global use of more than 1.8 million pounds in 2014 (Benbrook, 2016). In non resistant plants, glyphosate is widely believed to exert its herbicidal effect via inhibition of the 5-enolpyruvylshikimate-3-phosphate synthase, an enzyme of the shikimate pathway required for the biosynthesis of aromatic amino acids in plants and most microorganisms such as fungi, bacteria and some protozoans. As the shikimate pathway has no known physiologi-cal function in mammals, glyphosate was considered safe for humans. However, this view has been challenged by several studies conducted by researchers from various fields, leading to the assumption that agricul-tural spreading of glyphosate might bear health risks, including but not limited to carcinogenic, inflammatory and endocrine disruptive effects (Mesnage et al., 2015).
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论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2079-2080 )