Novel pluripotent stem cell lines for enriched grafting in Parkinson’s disease
Agustin Cota-Coronado
Lachlan H. Thompson
N. Emmanuel Diaz-Martinez
摘要：Parkinson’s disease (PD) is the second most common neurodegen-erative disease, affecting 1% of the population over 55 years of age and up to 4% of the population over 80 years of age (Blesa et al., 2012). This progressive and neurodegenerative condition results from an excessive loss of dopaminergic neurons (50–70%) of the substantia nigra pars compacta, leading to a significant decrease in dopamine (DA) levels in the striatum and consequently a func-tional deterioration of motor circuity (Blesa et al., 2012; Nielsen et al., 2016). The direct relationship between the loss of motor function and the degeneration of a single cell type makes PD an attractive prospect for cellular replacement therapy (Lindvall et al., 1990) and we are now on the verge of seeing the first clinical trials using human induced pluripotent stem cells (hiPSCs) as a source of transplantable dopamine neurons in clinical trials (Barker et al., 2017). The application of hiPSCs as a donor source for neural trans-plantation has progressed rapidly and may offer advantages over embryonic stem cells by avoiding ethical issues and potentially also complications related to immune response.
机标关键词：
资助基金：funds from Consejo Nacional de Ciencia y Tecnología (CONACyT)funds from Consejo Nacional de Ciencia y Tecnología ( 271307)funds from Consejo Nacional de Ciencia y Tecnología ( 272968)funds from Consejo Nacional de Ciencia y Tecnología ( to NEDM)
论文发表日期：2020-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 255-256 )