Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation
Deepak Jain
Sabrina Mattiassi
Eyleen L. Goh
Evelyn K.F. Yim
摘要：Extracellular matrix (ECM) influences cell differentiation through its structural and biochemical prop-erties. In nervous system, neuronal behavior is influenced by these ECMs structures which are present in a meshwork, fibrous, or tubular forms encompassing specific molecular compositions. In addition to contact guidance, ECM composition and structures also exert its effect on neuronal differentiation. This short report reviewed the native ECM structure and composition in central nervous system and peripheral nervous system, and their impact on neural regeneration and neuronal differentiation. Using topographies, stem cells have been differentiated to neurons. Further, focussing on engineered biomimicking topogra-phies, we highlighted the role of anisotropic topographies in stem cell differentiation to neurons and its recent temporal application for efficient neuronal differentiation.
机标关键词：
资助基金：The work was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery(NSERC 2016040)The work was supported by the Natural Sciences and Engineering Research Council of Canada (to DJ)The work was supported by the Natural Sciences and Engineering Research Council of Canada ( SM and EKFY)Collaborative Research and Training Experience (CREATE)Collaborative Research and Training Experience ( 401207296)Collaborative Research and Training Experience ( to SM and EKFY)
论文发表日期：2020-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 573-585 )
英文信息