Unfolded protein response in myelin disorders
Wensheng Lin
Sarrabeth Stone
摘要：Activation of the unfolded protein response in response to endoplasmic reticulum stress preserves cell viability and function under stressful conditions. Nevertheless, persistent, unresolvable activation of the unfolded protein response can trigger apoptosis to eliminate stressed cells. Recent studies show that the unfolded protein response plays an important role in the pathogenesis of various disorders of myelin, in-cluding multiples sclerosis, Charcot-Marie-Tooth disease, Pelizaeus-Merzbacher disease, vanishing white matter disease, spinal cord injury, tuberous sclerosis complex, and hypoxia-induced perinatal white matter injury. In this review we summarize the current literature on the unfolded protein response and the evi-dence for its role in the pathogenesis of myelin disorders.
机标关键词：
资助基金：grants from the National Institutes of Health (NS094151 and NS105689)grants from the National Institutes of Health ( both to WL)
论文发表日期：2020-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 636-645 )
英文信息