Relationship between MRI perfusion and clinical severity in multiple sclerosis
Maria Marcella Lagan
Laura Pelizzari
Francesca Baglio
摘要：Perfusion alterations within several brain regions have been shown in multiple sclerosis patients using dif-ferent magnetic resonance imaging (MRI) techniques. Furthermore, MRI-derived brain perfusion metrics have been investigated in association with multiple sclerosis phenotypes, physical disability, and cognitive impairment. However, a review focused on these aspects is still missing. Our aim was to review all the stud-ies investigating the relationship between perfusion MRI and clinical severity during the last fifteen years to understand the clinical relevance of these findings. Perfusion differences among phenotypes were observed both with 1.5T and 3T scanners, with progressive multiple sclerosis presenting with lower perfusion values than relapsing-remitting multiple sclerosis patients. However, only 3T scanners showed a statistically sig-nificant distinction. Controversial results about the association between MRI-derived perfusion metrics and physical disability scores were found. However, the majority of the studies showed that lower brain perfusion and longer transit time are associated with more severe physical disability and worse cognitive performances.
机标关键词：
资助基金：This work was in part funded by the Annette Funicello Research Fund for Neurological Diseases and by the Italian Ministry of Health (Ricerca Corrente 2018-2020)
论文发表日期：2020-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 646-652 )
英文信息