Role of CD20+ T cells in multiple sclerosis: implications for treatment with ocrelizumab
Stefan Gingele
Thomas Skripuletz
Roland Jacobs
摘要：Features of CD20+ T cells: CD20 is a membrane-spanning hosphopro-tein strongly expressed on the cell surface of B lineage cells and is widely regarded as a B cell specific marker. However, CD20 (Figure 1) is also expressed at a low level on a small subset of CD3+ T cells which therefore are sometimes referred to as CD20dimCD3+ T cells in contrast to CD20brightCD19+ B cells which represent the majority of cells expressing CD20 (Hultin et al., 1993). The amount of the CD20 antigen has been assessed to be 25 to 50 times higher on CD20+CD19+B cells compared to CD20+CD3+ T cells (Hultin et al., 1993). At first description of this cell population the frequency of these CD20+ T cells has been described to represent an average of 2.4% of all peripheral blood lymphocytes (50 healthy controls) (Hultin et al., 1993). In the largest characterized cohort with 142 healthy individuals CD20+CD3+T cells constituted a mean proportion of 1.6% (range from 0.1–6.8%) of all circulating CD3+ T cells and in absolute numbers accounted for approximately 28 cells/μL (Wilk et al., 2009).
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论文发表日期：2020-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 663-664 )