Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds
Melissa Schepers1
Nikita Martens2
Assia Tiane1
Kenneth Vanbrabant3
Hong-Bing Liu4
Dieter Lütjohann5
Monique Mulder2
Tim Vanmierlo1
1.Department of Neuroimmunology, Biomedical Research Institute, Hasselt University, European Graduate School of Neuroscience(EURON),Hasselt, Belgium;Department of Psychiatry & Neuropsychology, Division of Translational Neuroscience, School for Mental Health and Neuroscience, Maastricht University, European Graduate School of Neuroscience(EURON), Maastricht, The Netherlands2.Department of Internal Medicine, Laboratory of Vascular Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands3.Department of Neuroimmunology, Biomedical Research Institute, Hasselt University, European Graduate School of Neuroscience(EURON),Hasselt, Belgium;Institue for Clinical Chemistry and Clinical Pharmacology, Bonn, Germany4.Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China5.Institue for Clinical Chemistry and Clinical Pharmacology, Bonn, Germany
摘要：Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and polysaccharides.Over the last decades,seaweed-derived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological conditions.Therefore,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative disorders.In particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory properties.Though,the anti-inflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more interest.In this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.
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论文发表日期：2020-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 790-795 )
英文信息