Circular RNAs in early brain development and their influence and clinical significance in neuropsychiatric disorders
Chuan-Jun Zhuo1
Wei-Hong Hou2
De-Guo Jiang3
Hong-Jun Tian4
Li-Na Wang4
Feng Jia4
Chun-Hua Zhou5
Jing-Jing Zhu3
1.Department of Psychiatry and Genetics, School of Mental Health, Jining Medical University, Jining, Shandong Province, China;Department of Psychiatry and Molecular Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang Province, China;Department of Psychiatry and Imaging-Genetics and Co-morbidity (PNGC-Lab), Tianjin Anding Hospital, Tianjin Mental Health Center,Mental Health Teaching Hosp2.Department of Biochemistry and Molecular Biology, Medical College of Zhengzhou University, Zhengzhou, Henan Province, China;Department of Biology, University of North Carolina at Charlotte, Charlotte, NC, USA3.Department of Psychiatry and Molecular Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang Province, China4.Department of Psychiatry and Imaging-Genetics and Co-morbidity (PNGC-Lab), Tianjin Anding Hospital, Tianjin Mental Health Center,Mental Health Teaching Hospital, Tianjin Medical University;Department of Psychiatry, School of Basic Medical Research, Tianjin Medical University, Tianjin, China5.Department of Pharmacy, First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
摘要：Neuropsychiatric disorders represent a set of severe and complex mental illnesses,and the exact etiologies of which are unknown.It has been well documented that impairments in the early development of the brain contribute to the pathogenesis of many neuropsychiatric disorders.Currently,the diagnosis of neuropsychiatric disorders largely relies on subjective cognitive assessment,because there are no widely accepted biochemical or genetic biomarkers for diagnosing mental illness.Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNA (ncRNA) with a closed-loop structure.In recent years,there have been tremendous advances in our understanding of the expression profiles and biological roles of circRNAs.In the brain,circRNAs are particularly enriched and are expressed more abundantly in contrast to linear counterpart transcripts.They are highly active at neuronal synapses.These features make circRNAs uniquely crucial for understanding brain health,disease,and neuropsychiatric disorders.This review focuses on the role of circRNAs in early brain development and other brain-related processes that have been associated with the development of neuropsychiatric disorders.In addition,we discuss the potential for blood or cerebrospinal fluid circRNAs to be used as novel biomarkers in the early diagnosis of neuropsychiatric disorders.The findings reviewed here may provide new insight into the pathological mechanisms underlying the onset and progression of neuropsychiatric disorders.
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论文发表日期：2020-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 817-823 )
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