Neurodegenerative diseases as proteinopathies-driven immune disorders
Fausta Ciccocioppo1
Giuseppina Bologna1
Eva Ercolino1
Laura Pierdomenico1
Pasquale Simeone1
Paola Lanuti1
Damiana Pieragostino2
Piero Del Boccio2
Marco Marchisio1
Sebastiano Miscia1
1.Department of Medicine and Aging Science, University "G.d'Annunzio" of Chieti-Pescara, Chieti, Italy;Centre on Aging Sciences and Translational Medicine(Ce.S.I-MeT), University "G.d'Annunzio" of Chieti-Pescara, Chieti, Italy2.Centre on Aging Sciences and Translational Medicine(Ce.S.I-MeT), University "G.d'Annunzio" of Chieti-Pescara, Chieti, Italy;Department of Medical, Oral and Biotechnological Sciences, University "G.d'Annunzio" of Chieti-Pescara, Chieti, Italy
摘要：In the pathophysiology of neurodegenerative disorders,the role of misfolded protein deposition leading to neurodegeneration has been primarily discussed.In the last decade,however,it has been proposed a parallel involvement of innate immune activation,chronic inflammation and adaptive immunity in the neurodegeneration mechanisms triggered by proteinopathies.New insights in the neurodegenerative field strongly suggest a role for the immune system in the pathophysiology of neurodegenerative disorders.Therefore,the hypothesis underlining the modulation of the innate and the adaptive immune system in the events linked to brain deposition of misfolded proteins could open new perspectives in the setting of specific immunotherapeutic strategies for the treatment of neurodegenerative diseases.Therefore,we have reviewed the pathogenic hypothesis in neurodegenerative pathologies,underling the links between the deposition of misfolded protein mechanisms and the immune activation.
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论文发表日期：2020-05-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 850-856 )
英文信息