Adult neurogenesis from reprogrammed astrocytes
Brian B. Griffiths
Anvee Bhutani
Creed M. Stary
摘要：The details of adult neurogenesis, including environmental triggers, region specificity, and species ho-mology remain an area of intense investigation. Slowing or halting age-related cognitive dysfunction, or restoring neurons lost to disease or injury represent just a fraction of potential therapeutic applications. New neurons can derive from stem cells, pluripotent neural progenitor cells, or non-neuronal glial cells, such as astrocytes. Astrocytes must be epigenetically "reprogrammed" to become neurons, which can occur both naturally in vivo, and via artificial exogenous treatments. While neural progenitor cells are localized to a few neurogenic zones in the adult brain, astrocytes populate almost every brain structure. In this review, we will summarize recent research into neurogenesis that arises from conversion of post-mitotic astrocytes, detail the genetic and epigenetic pathways that regulate this process, and discuss the possible clinical rele-vance in supplementing stem-cell neurogenic therapies.
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资助基金：the American Heart Association, (No. 18POST33990395)American Heart Association, (No. 14FTF-19970029) This work was supported by the American Heart As-sociation, No. 18POST33990395(No. NS107445 (to CMS). Financial support)National Institutes of Health, (No. NS107445)
论文发表日期：2020-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 973-979 )
英文信息