Type XIX collagen: a promising biomarker from the basement membranes
Ana C. Calvo
Laura Moreno
Leticia Moreno
Janne M. Toivonen
Raquel Manzano
Nora Molina
Miriam de la Torre
Tresa López
Francisco J. Miana-Mena
María J. Mu?oz
Pilar Zaragoza
Pilar Larrod
Alberto García-Redondo
Rosario Osta
摘要：Among collagen members in the collagen superfamily, type XIX collagen has raised increasing interest in relation to its structural and biological roles. Type XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member, one main subclass of collagens in this superfamily. This collagen con-tains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different tissues. The molecular structure of type XIX collagen consists of five collagenous domains, COL1 to COL5, interrupted by six non-collagenous domains, NC1 to NC6. The most relevant domain by which this collagen exerts its biological roles is NC1 domain that can be cleavage enzymatically to release matricryptins, exerting anti-tumor and anti-angiogenic effect in murine and human models of cancer. Under physiological conditions, type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels, mainly in skeletal muscle and hippocampal and telencephalic interneurons in brain. Notwithstanding, in amyotrophic lateral sclerosis, altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic properties. Type XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1G93A mice and amyotrophic lateral sclerosis patients. This novel biological role highlights its nature as prognostic biomarker of disease progression in and as promis-ing therapeutic target, paving the way to a more precise prognosis of amyotrophic lateral sclerosis.
机标关键词：
资助基金：Institutode Salud Carlos III(Grant PI17/00949)Fondo Europeode Desarrollo Regional (FEDER) "Una manera de hacer Europa" from the European Union)Fondo Europeode Desarrollo Regional ( Centrode Investigación Biomédicaen Redsobre Enfermedades Neurodegenerativas(CIBERNED-612)Consolidated Groupsfrom Gobiernode Aragón. Financial support(Grant PI17/00949)Fondo Europeode Desarrollo Regional (FED-ER) "Una manera de hacer Europa" from the European Union)Fondo Europeode Desarrollo Regional ( Centrode Investigación Biomédicaen Redsobre Enfermedades Neurodegenerativas(CIBERNED-612)
论文发表日期：2020-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 988-995 )
英文信息