Vascular dysfunction in Alzheimer’s disease: a biomarker of disease progression and a potential therapeutic target
Karan Govindpani
Chitra Vinnakota
Henry J. Waldvogel
Richard L. Faull
Andrea Kwakowsky
摘要：Alzheimer’s disease (AD) is a progressive neurodegenerative dis-order and the predominant form of dementia. Since its initial de-scription by Alois Alzheimer in 1906, several advances have been made in our understanding of the progression of the disease and its clinical consequences, yet the underlying etiology remains conten-tious. Given the stereotyped patterns of cortical and hippocampal neuronal loss and the progressive degeneration of key neurotrans-mitter pathways, research has traditionally been focused on factors affecting neuronal viability, including the contribution of glial dysfunction to neuronal degeneration. From a clinical perspective, the fruits of this work have been underwhelming. Key pathological markers of the disease, including β-amyloid (Aβ) plaque formation and tau hyperphosphorylation, have yielded no effective therapies, highlighted by the recent discontinuations of several high profile Aβ immunotherapy trials. The few current symptomatic therapies for AD are predicated on the amelioration of cholinergic or gluta-matergic dysfunction. Aside from underscoring the inadequacy of current therapeutic approaches, this also points to the importance of alternative contributors to AD pathogenesis. In recent years, there has been a growing appreciation for the multimodal and mul-tifactorial nature of the condition; the case for combinatorial thera-pies is thus strong.
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论文发表日期：2020-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1030-1032 )