Human endogenous retroviruses:ammunition for myeloid cells in neurodegenerative diseases?
Joel Gruchot
David Kremer
Patrick Küry
摘要：Activation of myeloid cells by human endogenous retroviral entities: While the exact causes of neurological diseases such as multiple sclerosis (MS) or amyotrophic lateral sclerosis (ALS) are still elusive, there is evidence of a new category of pathogen-ic elements called human endogenous retroviruses (HERVs) which seem to contribute to their evolution and progression by exerting inflammatory and degenerative effects (Küry et al., 2018). HERVs are ancient retroviral elements which account for up to 8% of the human genome and it is known that envi-ronmental factors can trigger their (re-)expression (Küry et al., 2018). The resulting production of viral particles and/or pro-teins, especially from members of the HERV-W and HERV-K family, is strongly correlated with the onset and progression of neurological diseases, such as MS and ALS (Küry et al., 2018).
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论文发表日期：2020-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1043-1044 )