Targeting the P2X7 receptor in microglial cells to prevent brain inflammation
Lin-Hua Jiang1
Sébastien Roger2
1.School of Biomedical Sciences, Faculty of Biological Sciences,University of Leeds, Leeds, UK;Sino-UK Joint Laboratory of Brain Function and Injury and Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, HenanProvince, China2.EA4245, Transplantation, Immunology and Inflammation, Faculty of Medicine, University of Tours, Tours, France
摘要：Microglial cells are the key innate immune cells in the brain and they are crucial in maintaining brain parenchyma homeostasis. Under physiological conditions, microglial cells assume a ramified morphology with a small cell body and an extensive network of fine processes, which secrete neurotroph-ic factors and patrol the surroundings in search for pathogens and eliminate cellular debris via phagocytosis.
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论文发表日期：2020-07-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1245-1246 )