Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases
Jose A. Fernández-Albarral1
Rosa de Hoz2
Ana I. Ramírez2
Inés López-Cuenca1
Elena Salobrar-García1
María D. Pinazo-Durán3
José M. Ramírez4
Juan J. Salazar2
1.Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Madrid, Spain2.Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Madrid, Spain;Departamento de Inmunología, Oftalmología y ORL, Facultad de óptica y Optometría, Madrid, Spain3.Unidad de Investigación Oftalmológica Santiago Grisolia, Universidad de Valencia, Valencia, Spain4.Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Madrid, Spain;Departamento de Inmunología, Oftalmología y ORL, Facultad de Medicina, Madrid, Spain
摘要：Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It cur-rently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant, anxiolytic, hypolipidemic, anti-atherogenic, anti-hypertensive, antidiabetic, and anti-cancer properties. In addition, saffron has remarkable beneficial properties, such as anti-apoptotic, anti-inflammatory and antioxidant activities, due to its main metabolites, among which crocin and croce-tin stand out. Furthermore, increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases, both in experimental models and in clinical studies in patients. Currently, saffron supplementation is being tested for ocular neurodegenerative pathologies, such as diabetic retinopathy, retinitis pigmentosa, age-re-lated macular degeneration and glaucoma, among others, and shows beneficial effects. The present article provides a comprehensive and up to date report of the investigations on the beneficial effects of saffron extracts on the main neurodegenerative ocular pathologies and other ocular diseases. This review showed that saffron extracts could be considered promising therapeutic agents to help in the treatment of ocular neurodegenerative diseases.
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论文发表日期：2020-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 1408-1416 )
英文信息