LIM kinases in synaptic plasticity and their potential as therapeutic targets
éva Halász1
Ellen Townes-Anderson1
Weiwei Wang2
1.Department of Pharmacology, Physiology and Neuroscience, GraduateSchool of Biomedical Sciences, Rutgers, The State University of New Jersey, Newark, NJ, USA2.Grousbeck Gene Therapy Center, Schepens Eye Research Institute andMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA
摘要：LIM domain kinases (LIMKs), which modulate cytoskeletal dynamics, are found throughout the central nervous system. The synaptic junctions between neurons show structural alteration or plasticity during neurodevelopment, learning and memory formation, or after injury and disease; in some cases completely new connections form, while others are lost. This remodeling is under the control of the actin cytoskeleton and therefore is influenced by the activity of LIMKs (Scott and Olson, 2007). Recent reports discussed in this perspective shed light on the potential role of LIMK in hippocampal dendritic spines and photoreceptor presynaptic terminals and illustrate the importance of LIMK in nerve cell function.
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论文发表日期：2020-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1471-1472 )