Beneficial effects of AAV1-Rheb(S16H) administration in the adult hippocampus
Sang Ryong Kim
School of Life Sciences; BK21 plus KNU Creative BioResearch Group; Institute of Life Science & Biotechnology; Brain Science and Engineering Institute, Kyungpook National University, Daegu, Korea
摘要：Neurotrophic factors against neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD): A clear understanding of the etiology of neurodegenerative diseases, such as AD and PD remains elusive. Although there is still no therapy to prevent or block neurodegeneration, in vivo and in vitro experi-mental results have shown that the direct administration of neuro-trophic factors, such as brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF), and the induction of these neurotrophic factors via specific gene delivery may protect neurons against neurotoxicity in neurodegenerative disease models (Kim et al., 2012; Jeong et al., 2013, 2015). However, the application of neurotrophic factors to treat brain diseases is limited by the blood-brain barrier preventing macromolecular therapeutic agents from entering the central nervous system. Additionally, intra-cerebro-ventricular injection and intra-putaminal infusion of neurotrophic factors have led to limited penetration and distribution to the target brain areas (Peterson and Nutt, 2008; Nam et al., 2015). Neuro-trophic factors that induce the sustained delivery of the appropriate amount to the target areas can be considered a potential therapeutic strategy for neurodegenerative diseases, such as AD and PD.
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论文发表日期：2020-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1479-1480 )