TET2, an "ambiguous" player in inflammation
Ana María Espinosa-Oliva
Miguel Angel Burguillos
1.Departamento de Bioquímica y Biología Molecular, Facultad deFarmacia, Universidad de Sevilla, and Instituto de Biomedicinade Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC,Seville, Spain2.Departamento de Bioquímica y Biología Molecular, Facultad deFarmacia, Universidad de Sevilla, and Instituto de Biomedicinade Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC,Seville, Spain
摘要：Microglial cells, the "macrophages" from the central nervous sys-tem (CNS), perform a variety of roles necessary to keep the ho-meostasis in the healthy brain. However, microglial cells are best known for their role as "first responders" through initiation of an innate immune response against a wide variety of deleterious stim-uli in the brain. This controlled inflammatory response is beneficial and disappears once the deleterious stimuli are gone. But, it is also well-acknowledged that uncontrolled activation may transform into a chronic neuroinflammatory response which is partially respon-sible for the progression of the disease, for instance in Parkinson's disease (PD) and Alzheimer's disease (AD) (Shen et al., 2018). For this reason, microglia have become a target in the search for new therapeutic strategies to hinder the progression of different neuro-degenerative diseases, such as PD or AD.
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论文发表日期：2020-08-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1481-1482 )