Advanced diffusion magnetic resonance imaging in patients with Alzheimer's and Parkinson's diseases
Koji Kamagata1
Christina Andica1
Taku Hatano2
Takashi Ogawa2
Haruka Takeshige-Amano2
Kotaro Ogaki2
Toshiaki Akashi1
Akifumi Hagiwara1
Shohei Fujita1
Shigeki Aoki1
1.Department of Radiology,Juntendo University Graduate School of Medicine,Tokyo,Japan2.Department of Neurology,Juntendo University School of Medicine,Tokyo,Japan
摘要：The prevalence of neurodegenerative diseases is increasing as human longevity increases. The objective bio-markers that enable the staging and early diagnosis of neurodegenerative diseases are eagerly anticipated. It has recently become possible to determine pathological changes in the brain without autopsy with the advancement of diffusion magnetic resonance imaging techniques. Diffusion magnetic resonance imaging is a robust tool used to evaluate brain microstructural complexity and integrity, axonal order, density, and myelination via the micron-scale displacement of water molecules diffusing in tissues. Diffusion tensor im-aging, a type of diffusion magnetic resonance imaging technique is widely utilized in clinical and research settings; however, it has several limitations. To overcome these limitations, cutting-edge diffusion magnetic resonance imaging techniques, such as diffusional kurtosis imaging, neurite orientation dispersion and density imaging, and free water imaging, have been recently proposed and applied to evaluate the pathol-ogy of neurodegenerative diseases. This review focused on the main applications, findings, and future directions of advanced diffusion magnetic resonance imaging techniques in patients with Alzheimer's and Parkinson's diseases, the first and second most common neurodegenerative diseases, respectively.
机标关键词：
论文发表日期：2020-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 1590-1600 )
英文信息