Decoding epigenetic codes: new frontiers in exploring recovery from spinal cord injury
Bo-Yin Zhang1
Peng-Yu Chang2
Qing-San Zhu1
Yu-Hang Zhu1
Saijilafu3
1.Department of Orthopedic Surgery,China-Japan Union Hospital of Jilin University,Changchun,Jilin Province,China2.Department of Radiotherapy,The First Bethune Hospital of Jilin University,Changchun,Jilin Province,China3.Department of Orthopedics,The First Affliated Hospital of Soochow University,Suzhou,Jiangsu Province,China
摘要：Spinal cord injury that results in severe neurological disability is often incurable. The poor clinical outcome of spinal cord injury is mainly caused by the failure to reconstruct the injured neural circuits. Several in-trinsic and extrinsic determinants contribute to this inability to reconnect. Epigenetic regulation acts as the driving force for multiple pathological and physiological processes in the central nervous system by modu-lating the expression of certain critical genes. Recent studies have demonstrated that post-SCI alteration of epigenetic landmarks is strongly associated with axon regeneration, glial activation and neurogenesis. These findings not only establish a theoretical foundation for further exploration of spinal cord injury, but also provide new avenues for the clinical treatment of spinal cord injury. This review focuses on the epigenetic regulation in axon regeneration and secondary spinal cord injury. Together, these discoveries are a selection of epigenetic-based prognosis biomarkers and attractive therapeutic targets in the treatment of spinal cord injury.
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论文发表日期：2020-09-28
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 1613-1622 )
英文信息